[15]aneN4S: synthesis, thermodynamic studies and potential applications in chelation therapy

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[15]aneN4S: synthesis, thermodynamic studies and potential applications in chelation therapy

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Título: [15]aneN4S: synthesis, thermodynamic studies and potential applications in chelation therapy
Autor: Torres, N.; Gonçalves, S.; Fernandes, A. S.; Machado, J. F.; de Brito, M. J.; Oliveira, N. G.; Castro, M.; Costa, J.; Cabral, M. F.
Resumo: The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN4S with Mn2+, Fe2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+ and Pb2+ metal ions were further performed under the same experimental conditions. The results demonstrated that this compound has a higher selectivity and thermodynamic stability for Hg2+ and Cu2+, followed by Ni2+. The UV-visible-near IR spectroscopies and magnetic moment data for the Co(II) and Ni(II) complexes indicated a tetragonal distorted coordination geometry for both metal centres. The value of magnetic moment and the X-band EPR spectra of the Cu(II) complex are consistent with a distorted square pyramidal geometry.
URI: http://hdl.handle.net/10437/5619
Data: 2014-01-03


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