Autosomal dominant polycystic kidney disease in hemodialysis patients in southern Brazil

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Autosomal dominant polycystic kidney disease in hemodialysis patients in southern Brazil

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Title: Autosomal dominant polycystic kidney disease in hemodialysis patients in southern Brazil
Author: Alves, Everton Fernando; Tsuneto, Luiza Tamie; Pelloso, Sandra Marisa; Torres, Paulo Roberto Aranha; Otto, Guido Luis Gomes; Silva, Adaelson Alves; Obregon, José Miguel Viscarra; Silva, Leticia Nicoletti; Carvalho, Maria Dalva de Barros
Abstract: Introduction: Autosomal dominant polycystic kidney disease is the most common hereditary renal disease in humans. Objective: To examine the prevalence, clinical and laboratory characteristics of patients with polycystic kidneys and relate disease manifestations by gender. Methods: This was an observational and retrospective study. All the medical records of patients with polycystic kidneys who initiated hemodialysis between 1995 and 2012, in four centers that treat patients of the coverage area of the 15th regional health Paraná (Brazil), were analyzed. Results: The study included 48 patients with polycystic kidneys, the primary cause of stage 5 CKD. Disease prevalence was one in 10,912 people. The average age of dialysis initiation was 50.7 years and the follow-up time on dialysis until transplantation (36.5 months) was lower among men. Hypertension was the most frequent diagnosis in 73% of patients, predominantly in women (51.4%). The liver cyst was the most frequent extrarenal manifestations in men (60.0%). The death occurred in 10.4% of patients using hemodialysis, and 60% of men. The class of antihypertensive drug used was that acts on the renin-angiotensin system with higher frequency of use among women (53.3%). The post-dialysis urea was significantly higher in men. Conclusion: The prevalence of the disease is low among hemodialysis patients in southern Brazil. The differences observed between genders, with the exception of the post-dialysis urea, were not significant. The findings are different from those reported in North America and Europe.
URI: http://hdl.handle.net/10437/4654
Date: 2014-03-10


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